Protein structure and function презентация

Amino acids

Special amino acids
Glycine (G)
Smallest amino acid
Proline (P)
a.k.a helix-breaker
Histidine (H)
pKa ~ 7

Peptide bond

Ramachandran plot
? sheets
Right-handed
? helix
Left-handed
? helix

Secondary structures:
?-helices
Voltage-gated
K+ channel

? sheets
Parallel
Antiparallel
?-barrel

?-turn

Tertiary structure

Protein folding

Quaternary structure

Protein function: myoglobin

Haemoglobin

Haemoglobin switching between R and T states

Enzymes: biological catalysts
Case study: human carbonic anhydrase II (hCAII)

Inteins:
protein introns