Содержание
- 2. Bordetella, Francisella & Brucella
- 3. General Overview of Bordetella, Francisella & Brucella Extremely small Aerobic nonfermenters Gram-negative coccobacilli True pathogens: isolation
- 4. Human Disease & Associated Pathogens
- 6. Bordetella pertussis
- 7. Man is only natural host; obligate parasites of man Disease is highly communicable (highly infectious) Person-to-person
- 8. Incidence & Severity of Pertussis Cases in USA
- 9. Incidence of Pertussis in USA
- 10. Age Distribution & Severity of Pertussis Cases
- 11. Changes in Age Distribution for Pertussis Cases Blue = 1988 Orange = 1998
- 12. Clinical Progression of Pertussis Most infectious, but generally not yet diagnosed Inflammation of respiratory mucosal memb.
- 13. Fimbriae not primarily involved in adherence; Exotoxin & hemagglutinin mediate attachment specifically to ciliated epithelium of
- 14. Virulence Factors Associated with Bordetella pertussis
- 15. Laboratory Culture, Prevention & Treatment of Bordetella Inactivated whole bacterial cells and toxoid are prepared in
- 16. Differential Characteristics of Bordetella Species
- 18. Francisella tularensis
- 19. Francisella tularensis Infections
- 20. Francisella tularensis Infections (cont.)
- 21. Clinical Presentation of Tularemia NOTE: Also Gastrointestinal & Pneumonic forms of disease
- 22. Rabbits, ticks & muskrats are main reservoirs in US Two biochemical varieties F. tularensis bv. tularensis
- 23. Biochemical Variants (Biovar) of Francisella tularensis
- 24. Antiphagocytic capsule Thin lipid capsule present in pathogenic strains Facultative intracellular parasite that can survive in
- 25. Nonmotile Fastidious and slow-growing Requires cysteine-supplemented specialized media wi Requires prolonged growth Disease prevention: Avoidance of
- 26. Antibody Response to Francisella tularensis Infections
- 28. Brucella spp.
- 29. Brucella Infections
- 30. Brucella Infections (cont.)
- 31. Animals are natural reservoir Cattle, goats, sheep, swine, bison, elk, dogs, foxes, coyotes 500,000 human cases
- 32. Incidence of Brucellosis in USA
- 33. Brucella infect organs rich in erythritol (a sugar metabolized in preference to glucose) like breast, uterus,
- 34. Human Brucellosis & Associated Species Severe
- 35. Brucellosis in Humans Reportable disease Human brucellosis = Bang's disease, named for Bernhard Bang & Sir
- 36. Consumption of contaminated unpasteurized milk or direct contact with infected animal reservoir Disease associated with contact
- 37. Acute disease often develops with initial nonspecific symptoms of malaise, chills, fatigue, weakness, myalgias (muscles), weight
- 38. Plate agglutination test (a.k.a., Brucella ring test) diagnosing Brucella Drop of serum mixed with drop of
- 39. In 1934, the U.S. Department of Agriculture (USDA) established the National Brucellosis Eradication Effort which is
- 41. REVIEW Bordetella, Francisella & Brucella
- 42. General Overview of Bordetella, Francisella & Brucella Extremely small Aerobic nonfermenters Gram-negative coccobacilli True pathogens: isolation
- 43. Human Disease & Associated Pathogens REVIEW
- 44. Review of Bordetella pertussis
- 45. Bordetella pertussis Infections REVIEW
- 46. Bordetella pertussis Infections (cont.) REVIEW
- 47. Man is only natural host; obligate parasites of man Disease is highly communicable (highly infectious) Person-to-person
- 48. Changes in Age Distribution for Pertussis Cases Blue = 1988 Orange = 1998 REVIEW
- 49. Clinical Progression of Pertussis Most infectious, but generally not yet diagnosed Inflammation of respiratory mucosal memb.
- 50. Virulence Factors Associated with Bordetella pertussis REVIEW
- 51. Review of Francisella tularensis
- 52. Francisella tularensis Infections REVIEW
- 53. Francisella tularensis Infections (cont.) REVIEW
- 54. Clinical Presentation of Tularemia NOTE: Also Gastrointestinal & Pneumonic forms of disease REVIEW
- 55. Rabbits, ticks & muskrats are main reservoirs in US Two biochemical varieties F. tularensis bv. tularensis
- 56. Biochemical Variants (Biovar) of Francisella tularensis REVIEW
- 57. Review of Brucella spp.
- 58. Brucella Infections REVIEW
- 59. Brucella Infections (cont.) REVIEW
- 60. Animals are natural reservoir Cattle, goats, sheep, swine, bison, elk, dogs, foxes, coyotes 500,000 human cases
- 61. Brucella infect organs rich in erythritol (a sugar metabolized in preference to glucose) like breast, uterus,
- 62. Human Brucellosis & Associated Species Severe REVIEW
- 63. Brucellosis in Humans Reportable disease Human brucellosis = Bang's disease, named for Bernhard Bang & Sir
- 64. Consumption of contaminated unpasteurized milk or direct contact with infected animal reservoir Disease associated with contact
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