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- 3. Aerobic Gram-negative cocci often arranged in pairs (diplococci) with adjacent sides flattened (like coffe beans) Oxidase
- 4. Neisseria gonorrhoeae Neisseria meningitidis Important Human Pathogens Other species normally colonize mucosal surfaces of oropharynx and
- 5. Neisseria Associated Diseases (ophthalmia neonatorum)
- 6. Differential Characteristics of Commonly Isolated Neisseria spp.
- 8. Neisseria gonorrhoeae (gonococcus)
- 9. Readily transmitted by sexual contact Gram-negative diplococci flattened along the adjoining side Fastidious, capnophilic and susceptible
- 10. Neisseria gonorrhoeae in Urethral Exudates
- 11. Epidemiology of Gonorrhea Seriously underreported sexually-transmitted disease 350,000 reported cases in USA in 1998 Down from
- 12. Incidence of Gonorrhea in USA
- 13. IN MEN: Urethritis; Epididymitis Most infections among men are acute and symptomatic with purulent discharge &
- 14. Differences Between Men & Women with Gonorrhea (cont.) IN WOMEN: Cervicitis; Vaginitis; Pelvic Inflammatory Disease (PID);
- 15. IN WOMEN (cont.) : Disseminated Gonococcal Infection (DGI): Result of gonococcal bacteremia Often skin lesions Petechiae
- 16. Gonorrhea
- 17. Fimbriated cells attach to intact mucus membrane epithelium Capacity to invade intact mucus membranes or skin
- 18. Antiphagocytic capsule-like negative surface charge Only fimbriated (piliated) cells (formerly known as colony types T1 &
- 19. Llipooligosaccharide (LOS) (Lipid A plus core polysaccharide but no O-somatic antigen polysaccharide side chain) has endotoxin
- 20. Small, gram-negative diplococci in presence of polymorphonuclear leukocytes (PMN’s) seen microscopically in purulent urethral discharge Susceptible
- 21. Penicillin no longer drug of choice due to: Continuing rise in the MIC Plasmid-encoded beta-lactamase production
- 22. Analytic Performance of Different Laboratory Detection Methods for Nesseria gonorrhoeae NOTE: Importance of Sensitivity vs. Specificity
- 23. See Handout on Sensitivity & Specificity of Diagnostic Tests (Next two slides)
- 24. Analytic Performance of a Diagnostic Test
- 25. Sensitivity = Measure of True Positive Rate (TPR) = No. of True Pos. = No. of
- 27. Neisseria meningitidis (meningococcus)
- 28. Encapsulated small, gram-negative diplococci Second most common cause (behind S. pneumoniae) of community-acquired meningitis in previously
- 29. Following dissemination of virulent organisms from the nasopharynx: Meningitis Septicemia (meningococcemia) with or without meningitis Meningoencephalitis
- 30. Neisseria meningitidis in Cerebrospinal Fluid
- 31. Humans only natural hosts Person-to-person transmission by aerosolization of respiratory tract secretions in crowded conditions Close
- 32. Age Distribution of Meningococcal Disease in USA Lacking maternal antibody
- 33. Specific receptors (GD1 ganglioside) for bacterial fimbriae on nonciliated columnar epithelial cells in nasopharynx of host
- 34. Skin Lesions of Meningococcemia NOTE: Petechiae have coalesced into hemorrhagic bullae.
- 35. Following colonization of the nasopharynx, protective humoral immunity develops against the same or closely related organisms
- 36. Large numbers (e.g., >107cells/ml) of encapsulated, small, gram-negative diplococci (flattened along adjoining side) and polymorphonuclear leukocytes
- 37. Prevention and Treatment of Meningococcal Disease Penicillin is drug of choice for treatment in adjunct with
- 39. REVIEW of Neisseria
- 40. Aerobic Gram-negative cocci often arranged in pairs (diplococci) with adjacent sides flattened (like coffe beans) Oxidase
- 41. Neisseria Associated Diseases (ophthalmia neonatorum) REVIEW
- 42. Review of Neisseria gonorrhoeae
- 43. Readily transmitted by sexual contact Gram-negative diplococci flattened along the adjoining side Fastidious, capnophilic and susceptible
- 44. Summary of Neisseria gonorrhoeae REVIEW
- 45. Summary of Neisseria gonorrhoeae (cont.) REVIEW
- 46. Epidemiology of Gonorrhea Seriously underreported sexually-transmitted disease 350,000 reported cases in 1998 Found only in humans
- 47. REVIEW
- 48. Fimbriated cells attach to intact mucus membrane epithelium Capacity to invade intact mucus membranes or skin
- 49. REVIEW Virulence Factors Associated with Neisseria gonorrhoeae
- 50. See Handout on Sensitivity & Specificity of Diagnostic Tests (Next two slides)
- 51. Analytic Performance of a Diagnostic Test REVIEW
- 52. Sensitivity = Measure of True Positive Rate (TPR) = No. of True Pos. = No. of
- 53. Review of Neisseria meningitidis
- 54. Encapsulated small, gram-negative diplococci Second most common cause (behind S. pneumoniae) of community-acquired meningitis in previously
- 55. Summary of Neisseria meningitidis REVIEW
- 56. Summary of Neisseria meningitidis (cont.) REVIEW
- 57. Following dissemination of virulent organisms from the nasopharynx: Meningitis Septicemia (meningococcemia) with or without meningitis Meningoencephalitis
- 58. Humans only natural hosts Person-to-person transmission by aerosolization of respiratory tract secretions in crowded conditions Close
- 59. Age Distribution of Meningococcal Disease in USA REVIEW
- 60. Specific receptors (GD1 ganglioside) for bacterial fimbriae on nonciliated columnar epithelial cells in nasopharynx of host
- 61. Following colonization of the nasopharynx, protective humoral immunity develops against the same or closely related organisms
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