Ranscutol® CG презентация

Transcutol® CG
Ethoxydiglycol
Identity
Process
Mechanism of action
Clinical evaluation
Formulation & Regulation
Applications

Transcutol® CG
Ethoxydiglycol
Identity
Process
Mechanism of action
Clinical evaluation
Formulation & Regulation
Applications

Transcutol® CG
Properties
Efficacy booster
Powerful and versatile solubilizer
Odorless solvent for perfume extraction
Co-surfactant for microemulsions
Multi-functional
Characteristics
High purity (> 99.5%)
Excellent tolerance profile
Identity
INCI: Ethoxydiglycol

Transcutol® CG
INCI: Ethoxydiglycol
Oxygen – Carbon – Hydrogen
Dual nature
hydrophilic and lipophilic
Description
Chemical name: Diethylene glycol monoethyl ether
Small molecular weight
Dual nature: lipophilic and hydrophilic
Solubilization of both hydrophilic and lipophilic materials
Good affinity with the stratum corneum
Identity

Transcutol® CG
Ethoxydiglycol
Identity
Process
Mechanism of action
Clinical evaluation
Formulation & Regulation
Applications

Goal: 100% purified grade
Several in-process controls
Highly purified solvent
1st distillation to purify
2nd distillation to deodorize
Process

Goal: 100% activity
Purity > 99.5%
Process

Transcutol® CG
Ethoxydiglycol
Identity
Process
Mechanism of action
Clinical evaluation
Formulation & Regulation
Applications

Mode of action
Powerful
solubilizer
Diffusion
enhancer
“Push-effect”
Capacity to solubilize lipophilic actives in polar solvents
“Pull-effect”
Strong affinity with the lipids of the stratum corneum
Vehicle the actives inside the skin
Optimization of the efficacy of numerous actives
(Mura P. et al., 2000;Yazdanian M. et al., 1995;Watkinson A.C., Hadgraft J., and Bye A., 1991;Rojas de Garcia J., 1991a)

Measurement of hair split-ends formation of permed hair with an auto-brushing machine (accelerative method close to the actual hair care process):
Permed hair treated 30 min w/wo various solvents with low molecular weights (ethylene glycol, glycerol, glycinebetaine, D-panthenylalcohol, ethyl alcohol, urea) before a 60 min brushing.
Measurement of hair diameter by laser external-diameter apparatus.
in vitro substantiation – Interaction with hair internal proteins
Inhibition +20 % vs. glycerin
Method
Mode of action

Transcutol® CG
Ethoxydiglycol
Identity
Process
Mechanism of action
Clinical evaluation
Formulation & Regulation
Applications

Single application on the back of 10 volunteers of 2 spray formulas w/wo 20% Transcutol® CG [both formulas contain 5% DHA].
Measurement of skin color by chromametry at T0, T3, T5, T24, T48, T72 hours after application.
Use of the parameters L, a, b to calculate ΔE = √(Δa2 + Δb2 + ΔL2) and comparison of the results.
Self tanning efficacy booster
Method
Clinical evaluation
all differences between the 2 test sites are statistically significant (p<0.05)

Single application of 2 semi-permanent dye creams on natural, light brown hair locks, w/wo 5% Transcutol® CG.
Hair locks are rinsed with water, then color is measured by chromametry.
Then, 4 times, shampoo is applied, followed by chromametic measurement.
Calculation of ΔE = √(Δa2 + Δb2 + ΔL2) and comparison of the results.
Improvement of hair coloring
Evaluation of the influence of Transcutol® CG on the intensity and duration of hair color after application of dye creams
Method
Clinical evaluation
Aim
From the 2nd shampoo, differences between the 2 formulas are statistically significant (*p<0.05)
*
*
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Transcutol® CG
Ethoxydiglycol
Identity
Process
Mechanism of action
Clinical evaluation
Formulation & Regulation
Applications

Safety
Transcutol® has been used in the pharmaceutical industry for over 40 years and has an excellent safety profile
Formulation & Regulation
Ocular irritation (single application of 0.1 ml of pure product): non-irritant (score = 9.00).
Acute oral toxicity (single oral administration of the pure product at a dose level of 5,000 mg/kg): non-toxic (LD50 > 5,000 mg/kg).
Primary cutaneous irritation on humans (single application of pure product under occlusive patch for 48 hours): non-irritant.
Cutaneous sensitization on humans (9 successive applications of pure product under occlusive patch for 48 hours over a 3-week period 14 days of rest—challenge application): non-irritant and non-sensitizing.
Dermal toxicity by repeated applications for 28 days (daily application under patch for 6 hours/day for a 28-day period, at levels of 100, 300 and 1,000 mg/kg/day): non-toxic.

Formulation
Recommended use level: 2-30%*
Soluble in water
Soluble in alcohol
Insoluble in oils
Process:
Slowly add the active to the Transcutol® CG
Mix until the active is completely dissolve
*see restricted use levels in Europe
Formulation & Regulation
Add Transcutol® CG at a temperature < 50°C (risk of oxidation above)
*see restricted use levels in Europe

Regulatory status
Worldwide regulations
Worldwide approval (restricted use levels in Europe)
China: listed IECIC 2014-06
Australia TGA
Japan QD
Restricted use levels in Europe:
Rinse-off products: up to 10%
Oxidative hair dye formulations: up to 7%
Non-oxidative hair dye formulations: up to 5%
Spray products, fine fragrances, hair sprays, antiperspirants/deodorants: up to 2.6%
All cosmetic products: up to 2.6%
Formulation & Regulation

Transcutol® CG
Ethoxydiglycol
Identity
Process
Mechanism of action
Clinical evaluation
Formulation & Regulation
Applications

Sunscreens
Optimized UVA protection
Commonly used sun filter: Benzophenone-3
Crystalline powder with a tendency to crystallize out of many formulations, especially when < 3% in low oil content formulations
Transcutol® CG minimizes crystallization and increases efficacy
Applications
Optimized UVB protection
Commonly used sun filter: Octyl Methoxycinnamate (OMC)
In non-polar solvents, the UV curve of OMC will shift to a shorter wavelength
With Transcutol® CG, the UV curve of OMC remains centered at 308 nm ⇨ in sunscreen formulations with a low polarity oil vehicle, Transcutol® CG will increase the polarity of the medium
Sensoriality
Transcutol® CG helps to reduce the oiliness of the sunscreens

Toiletries
Antiperspirants
Transcutol® CG improves skin feel and decreases tacky feel
Transcutol® CG facilitates aluminum chlorohydrate dispersion and then increases efficacy
Applications
Soaps
Transcutol® CG decreases the dissolution time of Triclocarban, antimicrobial active
Transcutol® CG improves its uniform distribution throughout the soap

Others
Odorless solvent for perfume extraction
Superior solubilizing properties
Olfactive neutrality
Low irritation potential
Solubilization of essences and aromatic compounds
Anti-acne preparations
Solubilization of Benzoyl peroxide to avoid grinding of this potentially explosive oxidizing agent, and avoid grainy and scratching sensation
Co-surfactant for microemulsions
Applications

Transcutol® CG
Applications
Compatible with all types of formulations
Specific applications
Skin Care:
Anti-acne preparations
Sun Care:
Sunscreens
Self-tanning products
Hair care:
Conditioners
Hair dyes
Toiletries:
Antiperspirants
Antimicrobial soaps
Applications