Содержание
- 3. Classification Family Genus Species Micrococcaceae Micrococcus and Staphylococcus S. aureus S. saprophyticus S. epidermidis M. luteus
- 4. Gram-Positive Cocci Enterococcus (Group D CHO) γ hemolytic (α or β) Enterococcus faecalis, E. faecium FAMILY
- 5. Morphology
- 6. Morphology Staph vs. Strep Gram-positive cocci in clusters
- 7. Streptococcus Staphylococcus
- 8. Staphylococcus
- 12. See Overheads ~~~~~~~~~~ TSS Foodborne Intoxication ~~~~~~~~~~
- 15. Cell-Associated Virulence Factors Capsule or slime layer (glycocalyx) Peptidoglycan (PG) Teichoic acid is covalently linked to
- 16. Virulence Factors Extracellular Enzymes Coagulases (bound or free) Antigenic Hyaluronidase “spreading factor” of S. aureus Nuclease
- 17. Virulence Factors: Exotoxins Cytolytic (cytotoxins; cytolysins) Alpha toxin - hemolysin Reacts with RBCs Beta toxin Sphingomyelinase
- 18. Enterotoxin Exfoliative toxin (epidermolytic toxin) Pyrogenic exotoxins Virulence Factors: Exotoxins
- 19. Pathogenesis Pass skin – first line of defense Benign infection Phagocytosis Antibody Inflammatory response Chronic infections
- 20. Clinical Manifestations/Disease SKIN folliculitis boils (furuncles) carbuncles impetigo (bullous & pustular) scalded skin syndrome Neonates and
- 21. Clinical Manifestations/Disease Other infections Primary staphylococcal pneumonia Food poisoning vs. foodborne disease Toxic shock syndrome
- 22. Metastatic Infections Bacteremia Osteomyelitis ✔disease of growing bone Pulmonary and cardiovascular infection
- 24. Coagulase-Negative Staphylococci Staphylococcus epidermidis S. saprophyticus
- 27. Staphylococcal Lab ID & Diagnostic Tests Microscopic Lab isolation Coagulase positive S. aureus
- 28. Mannitol Salts Agar (MSA) Staphylococcus aureus
- 29. Catalase 2H2O2 ? O2 + 2H2O Streptococci vs. Staphylococci Differential Characteristics
- 31. Coagulase Fibrinogen ? Fibrin Differential Characteristics
- 33. Treatment Drain infected area Deep/metastatic infections semi-synthetic penicllins cephalosporins erythromycin clindamycin Endocarditis semi-synthetic penicillin + an
- 34. Prevention Carrier status prevents complete control Proper hygiene, segregation of carrier from highly susceptible individuals Good
- 36. REVIEW
- 37. Gram-Positive Cocci Enterococcus (Group D CHO) γ hemolytic (α or β) Enterococcus faecalis, E. faecium FAMILY
- 38. REVIEW Which features are only found in S. aureus? S. epidermidis S. aureus
- 39. REVIEW
- 40. REVIEW
- 41. REVIEW
- 42. REVIEW
- 43. REVIEW
- 45. Скачать презентацию