Содержание
- 2. Content Introduction Classification Structure Mechanism of action 4.1 Activation and regulation
- 3. ntroduction Enzyme-linked receptors (catalytic receptos) are a second major type of cell-surface receptor. They were recognized
- 4. Classification 1. Receptor tyrosine kinases 2. Tyrosine-kinase-associated receptors 3. Receptorlike tyrosine phosphatases 5. Receptor guanylyl cyclases
- 5. 1. Receptor tyrosine kinases Seven subfamilies of receptor tyrosine kinases: Note that the tyrosine kinase domain
- 7. Structure Ligand (Insulin) Tyrosine-kinase receptor Tyrosine-kinase domain (enzymatic)
- 8. Mechanism of action: activation
- 9. Mechanism of action: activation IRS-1 (insulin receptor substrate) IRS-1 stimulates the cascade of intercellular protein activation
- 10. Mechanism of action: regulation IRS-1 activates tyrosine phosphoproteinphosphotase Phosphorylation of serine/threonine residues decrease the affinity of
- 11. 2. Tyrosine-kinase-associated receptors Associate with intracellular proteins that have tyrosine kinase activity and also called “Cytokine
- 12. 2. Tyrosine-kinase-associated receptors
- 13. Mechanism of action: activation
- 14. Mechanism of action: regulation Inhibitory proteins
- 15. Mechanism of action: regulation Dephosphorylation by protein tyrosine phophotases
- 16. They respond to extracellular signaling proteins called growth factors that promote growth, proliferation, differentiation or cell
- 17. also known as a catalytic receptor •transmembrane receptor, where the binding of an extracellular ligand causes
- 18. Physiology and diseases involved in growth, proliferation, differentiation, or survival Because of this, their ligands are
- 19. Six classes of enzyme-linked receptors have thus far been identified: 1.Receptor tyrosine kinases phosphorylate specific tyrosines
- 20. In enzymology, a receptor protein serine/threonine kinase (EC 2.7.11.30) is an enzyme that catalyzes the chemical
- 21. Receptor serine/threonine kinases phosphorylate specific Serine/ Threonine There are two types of serine/threonine kinase receptors, both
- 22. Type I receptors are kept inactive by a portion of its cytosolic domain that blocks its
- 23. Serine/Threonine Kinase receptors play a role in the regulation of cell proliferation, programmed cell death (apoptosis),
- 24. Many serine/threonine protein kinases do not have their own individual EC numbers and use "2.7.11.1". These
- 28. Receptor Serine/Threonine Protein Kinase Smad-dependent signaling pathway activated by TGF-β Transforming growth factor (TGF-β) consists
- 29. The size and location of protein kinases
- 30. Receptor like tyrosine phosphatases Receptor like tyrosine phosphatases remove phosphate groups from tyrosines of specific intracellular
- 31. Based on their cellular localization, PTPases are also classified as: Receptor-like, which are transmembrane receptors that
- 32. Mechanism of action and highly conserved (signature) sequences of serine / threonine protein phosphatases. The catalytic
- 33. Specificity of serine/threonine phosphatases is largely determined by association of regulatory subunits that affect subcellular localisation
- 34. The regulatory subunit MYPT1 turns the broad-specificity PP1C (catalytic subunit) into a myosin regulatory-light chain-specific phosphatase
- 35. Clinical significance Serine/threonine kinase (STK) expression is altered in many types of cancer Serine/threonine protein kinase
- 36. The role of receptor-like tyrosine phosphatases is not yet clearly understood. They are thought to act
- 37. Classification of receptor-like protein tyrosine phosphatases (RPTPs) into eight subfamilies (R1-R8), based on sequence similarity among
- 38. Receptor guanylyl cyclases
- 39. Receptor guanylyl cyclases Single-pass transmembrane proteins with an extracellular binding site for a signal molecule and
- 40. Catalytic domain of human soluble guanylate cyclase 1 EC 4.6.1.2, also known as guanyl cyclase, guanylate
- 41. Guanylyl cyclase catalyzes the reaction … of guanosine triphosphate (GTP) 3',5'-cyclic guanosine monophosphate (cGMP)
- 42. Some of the protein kinases
- 43. Histidine-kinase-associated receptors
- 44. Histidine-kinase-associated receptors Activate a “two-component” signaling pathway in which the kinase phosphorylates itself on histidine and
- 45. Protein histidine kinase Crystallographic structure of ATP:protein-L-histidine N-phosphotransferase
- 46. Multifunctional, typically transmembrane, proteins of the transferase class of enzymes that play a role insignal transduction
- 47. Single monomer. Red residue is His-260, ligand (ADP and SO4) is yellow, ATP lid is magenta
- 48. The bacterial flagellar motor
- 49. Positions of the flagella on E. coli during swimming (A) Flagella rotate counterclockwise, they are drawn
- 50. The two-component signaling pathway that enables chemotaxis receptors to control the flagellar motor during bacterial chemotaxis
- 51. Conclusion (1) receptor tyrosine kinases (2) tyrosine-kinase-associated receptors (3) receptor serine/threonine kinases (4) transmembrane guanylyl cyclases
- 52. Some transmembrane tyrosine phosphatases, which remove phosphate from phosphotyrosine side chains of specific proteins, are thought
- 53. Tyrosine-kinase-associated receptors depend on various cytoplasmic tyrosine kinases for their action. These kinases include members of
- 54. Bacterial chemotaxis is mediated by histidine-kinase-associated chemotaxis receptors. When activated by the binding of a repellent,
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