Synthesis of Paclitaxel презентация

Октябрь 25, 2021

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Synthesis of Paclitaxel

Содержание

2. Retrosynthetic analysis of paclitaxel (1)
3. Synthesis of the C Ring of Paclitaxel
4. Preparation of the A−C Rings of Paclitaxel
5. Preparation of the ABC Precursor 4
6. Construction of ABC Ring of Paclitaxel 3
7. 2. Construction of the ABCD Ring and Formal Synthesis
8. Synthetic plan for paclitaxel (1) from ABC ring (3)
9. Construction of a Bridgehead Olefin by Chugaev Reaction 9
10. Synthesis of Taxoid 4
11. Synthesis of Takahashi’s Oxetane Intermediate
12. 3. Total synthesis of Taxol (baccatinIII) by Takashi
13. Abbreviation Thexylborane TBDPSCl tBuPh2SiCl TPAP Pr4NRuO4 NMO MS4A мол.сита 4A 3,5-DMP L-selectride EDCl TBHP
15. Luche reduction mechanism
16. Chugaev reaction mechanism
18. Скачать презентацию

Слайд 2

Retrosynthetic analysis of paclitaxel (1)

Слайд 3

Synthesis of the C Ring of Paclitaxel

Слайд 4

Preparation of the A−C Rings of Paclitaxel

Слайд 5

Preparation of the ABC Precursor 4

Слайд 6

Construction of ABC Ring of Paclitaxel 3

Слайд 7

2. Construction of the ABCD Ring and Formal Synthesis

Слайд 8

Synthetic plan for paclitaxel (1) from ABC ring (3)

Слайд 9

Construction of a Bridgehead Olefin by Chugaev Reaction
9

Слайд 10

Synthesis of Taxoid 4

Слайд 11

Synthesis of Takahashi’s Oxetane Intermediate

Слайд 12

3. Total synthesis of Taxol (baccatinIII) by Takashi

Слайд 13

Abbreviation
Thexylborane
TBDPSCl tBuPh2SiCl
TPAP Pr4NRuO4
NMO
MS4A мол.сита 4A
3,5-DMP
L-selectride
EDCl
TBHP

Слайд 14

Слайд 15

Luche reduction mechanism

Слайд 16

Chugaev reaction mechanism